MUCOSAVE® FG is the first ingredient specifically created for mucosal nutraceutical products. It is a blend of two herbal extracts containing polysaccharides of prickle pear cladodes (Opuntia ficus indica) and biophenols of olive leaves (Olea europaea). MUCOSAVE® FG is designed to support and maintain a healthy mucosal system and it may be helpful with occasional, minor gastric upsets (patent).


Physical protection of mucosal surface and lenitive-antinflammatory activity are two important requirements in designing oral formulations for the support of gastrointestinal health. MUCOSAVE® FG possesses all these effects: a strong mucoadhesive ability, due to Opuntia polysaccharides, and a lenitive effect from olive biophenols (1-6).



MUCOSAVE® FG can be used in oral formulations to protect sensitive mucosae (gastro-intestinal and oral) and to accelerate mucosal healing processes.


Experimental studies carried out on mucous membrane cell lines showed that MUCOSAVE® FG has a strong mucoadhesive activity (up to 60% of cell surface), higher than other bioadhesive polymers such as hyaluronic acid and alginate (30% and 5% respectively). This new in vitro model is based on the competition in the binding of lectin and tested polymers to the mucosal surface glycoproteins and it is able to evaluate mucoadhesivity by objective instrumental assessment (Fig.1).

  Fig.1 Evaluation of MUCOSAVE® FG activity by mucosal cell model.

Fig.2 Percentage inhibition of induced-ulceration in animal models.

Moreover, MUCOSAVE® FG can provide a strong protective action against gastro-intestinal diseases (5). In particular, an interesting synergistic antiulcer effect was obtained by animal models when MUCOSAVE® FG is used in combination with antiacid and cytoprotective agents.


1. Galati EM, et al., Antiulcer activity of Opuntia ficus indica (L.) Mill. (Cactaceae): ultrastructural study. J Ethnopharmacol 76:1-9 (2001).
2. Galati EM, et al., Study on the increment of the production of gastric mucus in rats treated with Opuntia ficus indica (L.) Mill. cladodes. J Ethnopharmacol 83:229-233 (2002).
3. Trombetta D, et al., Effect of polysaccharides from Opuntia ficus indica (L.) cladodes on the healing of dermal wounds in the rat. Phytomed 13:352-358(2006).
4. Dekanski D, et al., Gen Physiol Biophys 28:135-142 (2009).
5. Compositions for the treatment of gastro-esofageal reflux disease – PCT/EP/2010/000211.
6. Rizza L, et al., Caco-2 cell line as a model to evaluate mucoprotective properties. Int J Pharm 422(1-2):318-322 (2012).

Copyright © 2016 BIONAP S.r.l

  • Contrada Fureria Zona Industriale Ovest 95032 Piano Tavola Belpasso (CT) Italy
  • Tel: +39 095 7086560
  • Fax: +39 095 958435
Quality Research
Contact Us
Reserved Area
Sign up for our newsletter to receive news and updates.