COGNIGRAPE® is an ingredient developed by BIONAP to improve cognitive performance and prevent neurodegenerative age-related diseases. COGNIGRAPE® is a standardized powder extract containing high concentrations of active grape substances such as anthocyanins and proanthocyanidins (malvidin, delphinidin, epicatechins, catechins, etc.).


Normal brain ageing is associated with a progressive decline in motor and cognitive functions, often amplified in neurological disorders such as Alzheimer’s disease. The grape polyphenolic compounds contained in COGNIGRAPE® can be considered as a natural aid in decreasing cognitive deterioration and preventing neuropathology by improving synaptic plasticity and neuronal basal transmission in the specific brain area involved in cognitive activities (hippocampus), as well as in the protection of neurons against oxidative stress induced damage (1-3).


COGNIGRAPE® can be used in dietary supplements (capsules, tablets, granules, sachets) and functional foods designed to improve cognitive functions (learning and memory) and to reduce neurodegenerative disorder risks.


COGNIGRAPE® extract contains grape polyphenols (anthocyanins and proanthocyanidins) able to improve cognitive performance and protect the brain against neurodegenerative dysfunctions. In recent years, several scientific in vivo studies (1-4) have proven that:

  • Oral administration of grape polyphenols can improve the antioxidant status in the brain and prevent free-radical induced neuronal damage (2,3). It was observed that grape phenols are able to reduce deposition of lipid peroxidation marker lipofuscin (34- 41%) and to significantly inhibit the depletion of antioxidant enzyme activities, induced by ethanol treatment, in hippocampal formation involving in spatial and recent memory (2).
  • Grape proanthocyanidins intake, especially monomers, showed improved congnitive function in mouse model Alzheimer’s disease, promoting basal synaptic transmission in hippocampus slices and reducing amyloid beta-protein aggregation into high-molecular-weight oligomers in brain (1,4).

Moreover, scientific studies regarding behavioral in vivo tests (such as the Morris water maze test) were carried out to assess the beneficial effect of grape phenols in spatial learning and memory skills. In these studies, a significant improvement in performance scores was observed when the animals were fed with grape phenols compounds (1,2).

1. Wang J et al., Brain-targeted proanthocyanidin metabolites for Alzheimer’s Disease Treatment. J.Neurosci 32(15): 5144-5150 (2012).
2. Assuҫão M, et al., Red wine antioxidants protects hippocampal neurons against ethanol-induced damage: a biochemical, morphological and behavioral. Neuroscience 146:1581-1592(2007).
3. Scola G, et al., Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity. Nutrients 2:1048-1059 (2010).
4. Wang J, et al., Grape-derived polyphenolics prevent Aß oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer’s Disease. J Neurosci 28(25):6388-6392 (2008).

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