RENEGRAPE® is a skin peeling agent made up of an organic acid mixture (tartaric, malic, lactic, citric and gluconic acid) derived from grape (Vitis vinifera). As far back as the 17th century, ladies in the French Court of Louis XIV used to apply aged wine to their faces to keep their skin smooth and young. Nowadays, we know that the link between these anti-aging old remedies and the benefits obtained by red wine skin application is represented by a group of natural acids belonging to Alpha Hydroxy Acids (AHAs).


As reported in a recent clinical study published on Journal of Cosmetic Science, topical application of RENEGRAPE® stimulates cell turnover and produces a safe exfoliation well tolerated by the skin (1). RENEGRAPE® provides a peeling effect similar to glycolic and mandelic acids but without the undesirable side effects (skin irritation or inflammation).


RENEGRAPE® can be effectively used in several cosmetic formulations (creams, lotions, gels, bath foams etc.) for face and body. According to the used concentration, the result will be a soft or strong exfoliation. RENEGRAPE® is a liquid extract, 38-42% standardized in organic acids.

Recommended usage concentration: 10-50 % (w/w) for a soft/strong peeling effect.


In a recent clinical study (1), the effectiveness and safety of skin exfoliation produced by RENEGRAPE® have been evaluated by new experimental in vivo protocols and instrumental reflectance spectrophotometric method. To assess RENEGRAPE® efficacy, skin sites were treated at the beginning with tanning DHA solution and successively with RENEGRAPE®, glycolic acid and mandelic acid for 12 days. It was observed that RENEGRAPE® was able to increase the rate of skin regeneration (CTA%), with a significant reduction of time required to obtain complete skin renewal (Fig.1).

Fig.1 Skin cell turnover acceleration (CTA%)

In vivo safety models used in this study proved that RENEGRAPE® is extremely well tolerated by skin. After topical application, it produced only a mild erythema which naturally disappeared within few hours (Fig.2). Moreover, photosensitizing effect induced by long-time application is significantly lower than the glycolic and mandelic acid. Results obtained from in vivo studies, showed that RENEGRAPE® provides a good balance between efficacy and tolerability, in contrast with other agents commonly used in cosmetic products.

Fig.2 Trend of erythema (ΔE.I.) values vs time

1. Rizza L., et al., Comparative in vivo study of the efficacy and tolerance of exfoliating agents using reflectance spectrophotometric methods. J Cosmet Sci. 61(3):247-58 (2010).

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