In the narrow strip of the Calabria coast, several legends are told and passed down the generations about the mysterious origin of the “Green Gold”, the bergamot fruit. During the 17th century, the bergamot was used only for the essential oil contained in its peel, the external part of the fruit, dealing every other part as waste. But now, bergamot is recognized in its “whole beauty”; in fact, the heart of bergamot fruit contains active lipolytic principles, flavonoids, able to counteract the “orange peel” looking of the skin, by the reshape and improvement of skin firmness.

WHAT IT DOES

FLAVOSLIM is a powder ingredient containing active compounds (8-10% in flavonoids) of bergamot (Citrus bergamia Risso and Poiteau) juice. FLAVOSLIM is able to activate fat metabolism, reducing fat cell accumulation, inducing lipolytic effect, and inhibiting inflammatory processes and related consequences on adipose cells.

HOW TO USE

FLAVOSLIM is an ingredient created for body care formulations (gels, emulsions, massage products, foams, etc) aimed at reduce cellulite and loss of skin tone and improve firmness and tonicity.

Recommended usage concentration: 1-2% w/w

FLAVOSLIM ACTION ON ADIPOCYTES: SCIENTIFIC RESEARCH

Cellulite is a complex and multifactorial disorder of the subcutaneous fat layer. It can involve several mechanisms such as local fat accumulation, alteration of the extracellular matrix and inflammatory processes. Flavonoids contained in bergamot fruits are active compounds showing to own remarkable anti-oxidant activity and inflammatory effect on keratinocytes (1). In particular, they have proven to induce a strong reduction of glycosaminoglycan (GAG) synthesis induced by proinflammatory mediators. This appears to be a very interesting result in cellulite treatment because chronic tissue inflammation, occurring in skin affected by cellulite, leads to the synthesis and proliferation of dermal hydrophilic GAGs. In their turn, GAGs induce water retention (oedema), which provokes tissue hypoxia, cellular changes and, as a consequence, also the worsening of skin cellulite appearance (2). FLAVOSLIM ingredient has been evaluated on adipocytes metabolism using mesenchymal stem cells (MSCs) from adipose tissue during adipogenic differentiation (3). FLAVOSLIM was able to induce lipolytic effect both on differentiated MSCs in adipocytes and during adipogenic differentiation. In fact, adipocytes treated with FLAVOSLIM showed no toxicity (MTT test), a conspicuous reduction of cell sizes as well as the suppression of intracellular lipid droplets accumulation (Fig 1). Moreover, it is able to modulate production of AMPK (5’-adenosine monophosphate-activated protein kinase) that seems to inhibit adipogenesis through activation of lipase enzymes such as adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and monoacylglycerol lipase (MAGL) (3).

Fig.1 Images of adipocyte cells not treated (control) and after 14 days of treatment with FLAVOSLIM at different concentrations (10 µg/ml – 100 µg/ml)

REFERENCES
1. Graziano A., et al., Protective effects of an extract from Citrus bergamia against inflammatory injury in interferon- gamma and histamine exposed human keratinocytes. Life science 90:968-974 (2012).
2. De la Casa Almeida M., et al., Cellulite’s aetiology: a review. JEADV 27:273-278 (2013).
3. Bionap report. Effect of bergamot flavonoids extract on adipocytes cells (2014).

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